%0 Journal Article %J Obesity (Silver Spring) %D 2011 %T Sex-specific HDL cholesterol changes with weight loss and their association with anthropometric variables: the LIFE study. %A Yatsuya, Hiroshi %A Jeffery, Robert W %A Erickson, Darin J %A Welsh, Ericka M %A Flood, Andrew P %A Jaeb, Melanie A %A Laqua, Patricia S %A Mitchell, Nathan R %A Langer, Shelby L %A Levy, Rona L %K Anthropometry %K Blood Glucose %K Cholesterol, HDL %K Female %K Humans %K Insulin %K Male %K Middle Aged %K Obesity %K Sex Factors %K Subcutaneous Fat %K Triglycerides %K Waist-Hip Ratio %K Weight Loss %X

Decrease in the level of high-density lipoprotein cholesterol (HDLC) has been observed in women who start dieting, but not in men. Patterns of HDLC change during intentional weight loss through 30-months of follow-up, and their association with changes in anthropometric measurements were examined in obese women (N = 112) and men (N = 100). Missing HDLC values at 6-, 12-, 18-, and 30-month follow-up (N = 16, 34, 55, and 50, respectively) due to dropout were imputed by multiple imputation. Mean ages and BMIs of subjects at baseline were 47.2 years and 34.8 kg/m(2) for women, and 50.4 years and 35.0 kg/m(2) for men. On average, participants lost weight steadily for 12 months, followed by slow regain. During the first 6 months, HDLC decreased significantly in women (-4.1 mg/dl, P = 0.0007), but not in men. Significant HDLC increases were observed in both men and women from 6- to 12-month follow-up. HDLC changes in women were positively associated with changes in hip circumference from baseline to 12-month independent of changes in triglycerides (TG), glucose, and insulin. Rapid decrease of predominantly subcutaneous fat in the femoral and gluteal area might be associated with HDLC decrease in women during initial weight loss.

%B Obesity (Silver Spring) %V 19 %P 429-35 %8 2011 Feb %G eng %N 2 %R 10.1038/oby.2010.216 %0 Journal Article %J Prev Med %D 2010 %T Maintenance-tailored therapy vs. standard behavior therapy for 30-month maintenance of weight loss. %A Levy, Rona L %A Jeffery, Robert W %A Langer, Shelby L %A Graham, Dan J %A Welsh, Ericka M %A Flood, Andrew P %A Jaeb, Melanie A %A Laqua, Patricia S %A Finch, Emily A %A Hotop, Annie M %A Yatsuya, Hiroshi %K Adult %K Behavior Therapy %K Humans %K Male %K Middle Aged %K Obesity %K Weight Gain %K Weight Loss %X

OBJECTIVE: To assess differences in weight regain one year after an 18-month obesity treatment with standard behavior therapy (SBT) or maintenance-tailored therapy for obesity (MTT).

METHOD: 213 obese adult volunteers were treated for 18 months using SBT with fixed behavioral prescriptions or MTT that employed varied behavioral prescriptions with treatment breaks. Follow-up analysis focused on weight maintenance after a year of no contact. The trial was conducted at the University of Minnesota between 2005 and 2009.

RESULTS: Mean (SD) weight change between 18 and 30 months for participants in the SBT group was +4.1 kg (4.4) compared to +2.8 kg (4.5) in the MTT group. This is a 31% reduction in weight regain in MTT relative to SBT (p=0.078). This trend toward better maintenance in MTT versus SBT was due primarily to superior differential maintenance in MTT participants in the highest tertile of total weight loss at 18 months, i.e. MTT participants in this tertile regained 4 kg less than SBT participants between 18 and 30 months.

CONCLUSIONS: The MTT approach with varied content and timing produced more desirable patterns of weight loss maintenance than the traditional SBT approach, especially among individuals who had achieved greater initial weight loss.

%B Prev Med %V 51 %P 457-9 %8 2010 Dec %G eng %N 6 %R 10.1016/j.ypmed.2010.09.010