%0 Journal Article %J J Womens Health (Larchmt) %D 2011 %T Diabetes and depression in pregnancy: is there an association? %A Katon, Jodie G %A Russo, Joan %A Gavin, Amelia R %A Melville, Jennifer L %A Katon, Wayne J %K Adult %K Attitude to Health %K Cohort Studies %K Comorbidity %K Cross-Sectional Studies %K Depression %K Diabetes, Gestational %K Female %K Humans %K Pregnancy %K Pregnancy in Diabetics %K Prenatal Care %K Prevalence %K Prospective Studies %K Quality of Life %K Risk Factors %K United States %K Women's Health %K Young Adult %X

BACKGROUND: Prior studies have reported inconsistent findings regarding the association of antenatal depression with pregnancy-related diabetes. This study examined the association of diabetes and antenatal depression.

METHODS: We conducted a cross-sectional analysis of baseline data from a prospective cohort study of pregnant women receiving prenatal care at a single University of Washington Medical Center clinic between January 2004 and January 2009. The primary exposure was diabetes in pregnancy (no diabetes, preexisting diabetes, or gestational diabetes [GDM]). Antenatal depression was defined by the Patient Health Questionnaire-9 (PHQ-9) score or current use of antidepressants. Antenatal depression was coded as (1) any depression (probable major or minor depression by PHQ-9 or current antidepressant use) and (2) major depression (probable major depression by PHQ-9 or current antidepressant use). Logistic regression was used to quantify the association between diabetes in pregnancy and antenatal depression.

RESULTS: The prevalences of preexisting diabetes, GDM, any antenatal depression, and major antenatal depression were 9%, 18%, 13.6%, and 9.8%, respectively. In the unadjusted analysis, women with preexisting diabetes had 54% higher odds of any antenatal depression compared to those without diabetes (odds ratio [OR] 1.54, 95% confidence interval [CI] 1.08-2.21). After adjusting for important covariates the association was attenuated (OR 1.16, 95% CI 0.79-1.71). Results were similar for antenatal major depression. GDM was not associated with increased odds for any antenatal depression or antenatal major depression.

CONCLUSIONS: Neither preexisting diabetes nor GDM was independently associated with increased risk of antenatal depression.

%B J Womens Health (Larchmt) %V 20 %P 983-9 %8 2011 Jul %G eng %N 7 %R 10.1089/jwh.2010.2662 %0 Journal Article %J Arch Womens Ment Health %D 2011 %T Prevalence and correlates of suicidal ideation during pregnancy. %A Gavin, Amelia R %A Tabb, Karen M %A Melville, Jennifer L %A Guo, Yuqing %A Katon, Wayne %K Adult %K Attitude to Health %K Comorbidity %K Confidence Intervals %K Cross-Sectional Studies %K Depression %K Ethnic Groups %K Female %K Humans %K Logistic Models %K Odds Ratio %K Pregnancy %K Pregnancy Complications %K Prenatal Care %K Prevalence %K Quality of Life %K Risk Factors %K Suicidal Ideation %K United States %K Young Adult %X

Data are scarce regarding the prevalence and risk factors for antenatal suicidal ideation because systematic screening for suicidal ideation during pregnancy is rare. This study reports the prevalence and correlates of suicidal ideation during pregnancy. We performed cross-sectional analysis of data from an ongoing registry. Study participants were 2,159 women receiving prenatal care at a university obstetric clinic from January 2004 through March 2010. Multiple logistic regression identified factors associated with antenatal suicidal ideation as measured by the Patient Health Questionnaire. Overall, 2.7% of the sample reported antenatal suicidal ideation. Over 50% of women who reported antenatal suicidal ideation also reported major depression. In the fully adjusted model antenatal major depression (OR = 11.50; 95% CI 5.40, 24.48) and antenatal psychosocial stress (OR = 3.19; 95% CI 1.44, 7.05) were positively associated with an increased risk of antenatal suicidal ideation. We found that being non-Hispanic White was associated with a decreased risk of antenatal suicidal ideation (OR = 0.51; 95% CI 0.26-0.99). The prevalence of antenatal suicidal ideation in the present study was similar to rates reported in nationally representative non-pregnant samples. In other words, pregnancy is not a protective factor against suicidal ideation. Given the high comorbidity of antenatal suicidal ideation with major depression, efforts should be made to identify those women at risk for antenatal suicidal ideation through universal screening.

%B Arch Womens Ment Health %V 14 %P 239-46 %8 2011 Jun %G eng %N 3 %R 10.1007/s00737-011-0207-5